Volume 18, No. 6, 2021
A Review: Diabetics Leading To Ckd
Dr. Mohammed Shoiab M.D , Dr. Bhaben Choudhury MS Ph.D , Dr. Saniya Hafiz , Dr. Shyam Shekar Choudhury
Abstract
Chronic kidney disease is a common chronic consequence of diabetes mellitus that has a poor prognosis and can progress to end-stage renal disease if not managed. The multifaceted pathophysiology of Chronic kidney disease (CKD), which includes both hemodynamic & metabolic variables, makes it challenging to design effective therapeutic therapies. As the symptoms appear quite late, an early detection is the key to prevent further development. Several therapeutic and novel agents are developed that target specific pathophysiological pathways and interrupt the process. Some of the treatment agents are evaluated in clinical studies and some are under investigations to establish their safety and efficacy. In India, lack of education and poor diagnosis are important factors that increase the prevalence of DKD. The available diagnosis measures need to be adopted in clinical routine practice and awareness of the disease among the patients, especially the patients with prediabetes may be beneficial along with the current treatments available. Even though the characteristic clinical introduction of Chronic kidney disease ( ckd is categorized by just a steady crawl from nephropathy to normal buminuria and therefore by endothelial dysfunction at the important developmental and progressive decline of renal function at the late stage, recent epidemiological studies have indicated that DKD people with the disease have quite a wide range of clinical presentations and rates of progression to ESRD. Some DKD patients exhibit overall reduction in glomerular filtration rate absent renal disease, however tubular histology represents a major microvascular as well as intervening degradation. Individuals with DKD are now more sensitive to acute nephrotoxicity, which may also result in interstitial fibrosis. A significant number of people with type 2 diabetes with renal disease may very well have underlying impaired glucose tolerance glomerular illness, necessitating a liver examination for evaluation of patients.
Pages: 668-681
Keywords: DKD, filtration, glomerular, clinical presentation Diabetic kidney disease, diabetes, chronic kidney disease, albuminuria, glomerular filtration rate